Welcome to PharmTao’s RNAi Portal!

 

PharmTao Home

RNAi Glossary

 

Dicer: An enzyme that produces small RNA molecules (miRNAs and siRNAs) through cleaving double-stranded RNA into nucleotides of 21-23 bp.

miRNA: A non-specific RNA class that is generated when Dicer cleaves double-strand RNA to produce single stranded nucleotides. miRNA inhibits the process of RNA translation into protein without changing mRNA stability.

RNA interference (RNAi): Refers to the phenomenon that small double-stranded RNA (small interference RNA or siRNA) can cause effective sequence-specific silence of gene expression.

RNA-induced silencing complex (RISC): A siRNA-guided endonuclease that catalyzes the cleavage of a single phosphodiester bond on the RNA target.

Small interfering RNA (siRNA): 21-23-nt double-strand RNA that is produced by the cleavage of dsRNA through the dicer enzyme. siRNA mediates post-transcriptional gene silencing (PTGS) through leading RISC to the homologous endogenous mRNA to cleave the transcript.

 

RNAi Databases and Web Sources

 

Category	Databases and Web Sources	Note
Web resources	RNAi at elegansNet
	The RNA World Website
	RNAi Resources
Databases and tools	RNAi Database	Ovary cDNA study
	The RNAi database
	siRNA Design Tools
	RNAi Phenotype Search
Education	General Information (Macalester College)
	RNAi page (M. McManus)
	Nature Web Focus
	RNAi (Ahringer lab)
	Genome-wide RNAi based screen for genes important in cell division

Copyright © 2005 PharmTao.com. All Rights Reserved.