Recent Discoveries in Aging
Pharmacogenomics
(1990-2005)
à
Association between genotype at an exonic SNP in
DISC1 and normal cognitive aging.
Thomson PA, Harris SE, Starr JM, Whalley LJ, Porteous DJ, Deary
IJ.
Neurosci Lett. 2005 Jul 26.
à
Oxidative state in platelets and erythrocytes in
aging and Alzheimer's disease.
Kawamoto EM, Munhoz CD, Glezer I, Bahia VS, Caramelli P, Nitrini
R, Gorjao R, Curi R, Scavone C, Marcourakis T.
Neurobiol
Aging. 2005 Jun;26(6):857-64.
à
Reduced insulin/IGF-1 signalling and human
longevity.
van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW,
Zwaan BJ, Slagboom PE, Westendorp RG.
Aging
Cell. 2005 Apr;4(2):79-85.
à
Is the Val16Ala manganese superoxide dismutase
polymorphism associated with the aging process?
Taufer M, Peres A, de Andrade VM, de Oliveira G,
Sa G, do Canto ME, dos Santos AR, Bauer ME, da Cruz IB.
J Gerontol
A Biol Sci Med Sci. 2005 Apr;60(4):432-8.
à
Association between a variation in the
phosphodiesterase 4D gene and bone mineral density.
Reneland RH, Mah S, Kammerer S, Hoyal CR, Marnellos G, Wilson SG,
Sambrook PN, Spector TD, Nelson MR, Braun A.
BMC Med
Genet. 2005 Mar 7;6(1):9.
à
Interleukin-6 -174G/C polymorphism and longevity:
a follow-up study.
Hurme M, Lehtimaki T, Jylha M, Karhunen PJ, Hervonen A.
Mech
Ageing Dev. 2005 Mar;126(3):417-8.
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Single nucleotide polymorphisms: aging and
diseases.
Bessenyei B, Marka M, Urban L, Zeher M, Semsei I.
Biogerontology. 2004;5(5):291-303.
à
The catalase -262C/T promoter polymorphism and
aging phenotypes.
Christiansen L, Petersen HC, Bathum L, Frederiksen H, McGue M,
Christensen K.
J Gerontol
A Biol Sci Med Sci. 2004 Sep;59(9):B886-9.
à
Association between longevity and cytokine gene
polymorphisms. A study in Sardinian centenarians.
Pes GM, Lio D, Carru C, Deiana L, Baggio G, Franceschi C,
Ferrucci L, Oliveri F, Scola L, Crivello A, Candore G, Colonna-Romano G, Caruso
C.
Aging Clin
Exp Res. 2004 Jun;16(3):244-8.
à
Beta 2-adrenergic receptor polymorphisms and
haplotypes are associated with airways hyperresponsiveness among nonsmoking men.
Litonjua AA, Silverman EK, Tantisira KG, Sparrow D, Sylvia JS,
Weiss ST.
Chest.
2004 Jul;126(1):66-74.
à
A polymorphic marker in the first intron of the
Werner gene associates with cognitive function in aged Danish twins.
Bendixen MH, Nexo BA, Bohr VA, Frederiksen H, McGue M, Kolvraa S,
Christensen K.
Exp
Gerontol. 2004 Jul;39(7):1101-7.
à
P-glycoprotein function in the elderly.
Brenner SS, Klotz U.
Eur J Clin Pharmacol.
2004 Apr;60(2):97-102.
à
Association analysis of the SHC1 gene locus with
longevity in the Japanese population.
Kamei H, Adati N, Arai Y, Yamamura K, Takayama M, Nakazawa S,
Ebihara Y, Gondo Y, Akechi M, Noguchi T, Hirose N, Sakaki Y, Kojima T.
J Mol Med.
2003 Nov;81(11):724-8.
à
Single-nucleotide polymorphism of the
urokinase-plasminogen activator gene during aging and transformation of human
diploid kidney cell cultures.
Beqaj SH, Post D, Ryan JM.
In Vitro
Cell Dev Biol Anim. 2003 Sep-Oct;39(8-9):343-7.
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Cardiovascular pharmacogenetics in the SNP era.
Mooser V, Waterworth DM, Isenhour T, Middleton L.
J Thromb
Haemost. 2003 Jul;1(7):1398-402.
à
Amino acid variant in the kinase binding domain
of dual-specific A kinase-anchoring protein 2: a disease susceptibility
polymorphism.
Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM,
Nelson MR, Sing CF, Cantor CR, Taylor SS, Braun A.
Proc Natl
Acad Sci U S A. 2003 Apr 1;100(7):4066-71.
à
In vitro IL-6 production by EBV-immortalized B
lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in
IL-6 gene: a model to study the genetic basis of inflamm-aging.
Olivieri F, Bonafe M, Giovagnetti S, Stecconi R, Cardelli M,
Cavallone L, Spazzafumo L, Marchegiani F, Carrieri G, Mugianesi E, Giampieri C,
Centurelli M, Moresi R, Tesei S, Lisa R, Viticchi C, Falsetti L, Salvioli S,
Franceschi C.
Mech
Ageing Dev. 2003 Apr;124(4):549-53.
à
A delta-aminolevulinic acid dehydratase (ALAD)
polymorphism may modify the relationship of low-level lead exposure to uricemia
and renal function: the normative aging study.
Wu MT, Kelsey K, Schwartz J, Sparrow D, Weiss S, Hu H.
Environ
Health Perspect. 2003 Mar;111(3):335-41.
à
DNA variability of human genes.
Schneider JA, Pungliya MS, Choi JY, Jiang R, Sun XJ, Salisbury
BA, Stephens JC.
Mech
Ageing Dev. 2003 Jan;124(1):17-25.
à
Coding variants in human double-strand break DNA
repair genes.
Ruttan CC, Glickman BW.
Mutat Res.
2002 Nov 30;509(1-2):175-200.
à
Aging, carotid artery distensibility, and the
Ser422Gly elastin gene polymorphism in humans.
Hanon O, Luong V, Mourad JJ, Bortolotto LA,
Jeunemaitre X, Girerd X.
Hypertension. 2001 Nov;38(5):1185-9.
à
Adaptive evolution of a candidate gene for aging
in Drosophila.
Schmidt PS, Duvernell DD, Eanes WF.
Proc Natl
Acad Sci U S A. 2000 Sep 26;97(20):10861-5.
à
Association between LDLR polymorphism and
diseases in the Japanese population: aging and distribution of the polymorphism.
Hara M, Takada A, Ro A, Saito K, Kido A.
Forensic
Sci Int. 2000 Sep 11;113(1-3):133-7.
à
Aging affects the association between endothelial
nitric oxide synthase gene polymorphism and acute myocardial infarction in the
Korean male population.
Park JE, Lee WH, Hwang TH, Chu JA, Kim S, Choi YH, Kim JS, Kim DK,
Lee SH, Hong KP, Seo JD, Lee WR.
Korean J
Intern Med. 2000 Jan;15(1):65-70.
à
Aging. Polymorphism, compartmentalization and
environmental impact.
Cinader
B.
Immunol
Lett. 1994 Jun;40(3):213-7.
à
Analysis of collagen type III by uninterrupted
sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting:
changes in collagen type III polymorphism in aging rats.
Takasago T, Nakamura K, Kashiwagi S, Inoue S, Ito H, Takeo K.
Electrophoresis. 1992 Jun;13(6):373-8.
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