Translational Medicine and Drug Discovery

    May 25, 2016
    Systems Biology

    Recent development in translational medicine provides a connection between basic scientific studies and clinical practice. Such an initiative may support the patient-centered objectives in both research and clinical environments. It may also improve the drug discovery procedure by allowing for a more robust and systems-based pathophysiological understanding of diseases and drug responses. Such approaches may help improve the identification of drug targets and the optimization of drug candidates (Galizzi et …Read the Rest

    Systems Biology Approaches and Drug Design

    May 19, 2016
    Systems Biology

    The reductionist way of “one gene-one disease-one drug” has made it difficult for the discovery of more effective drugs.  In …Read the Rest

    Genetic Networks and Biomarkers

    May 15, 2016
    Systems Biology

    The post-genomic research based on large cohorts of preclinical studies have produced multi-dimensional genetic and transcriptomic data sets. The revelation …Read the Rest

    Systems Biology and Companion Diagnostics

    May 11, 2016
    Systems Biology

    The development in high-throughput (HTP) technologies and computational biology may help define the next generation of biomarkers. By providing an …Read the Rest

    Biomarkers for Inflammatory Breast Cancer

    May 8, 2016
    Systems Biology

    Inflammatory breast cancer (IBC) is an aggressive type of breast cancers (BC). Currently only a few specific genetic biomarkers or …Read the Rest

    Challenges in Biomarker Discovery

    April 29, 2016
    Biomarkers

    Although biomarkers have been considered more and more important, it is still very difficult to identify and validate effective and …Read the Rest

    Biomarkers of Seasonal Allergic Rhinitis (SAR)

    April 26, 2016
    Biomarkers

    Seasonal allergic rhinitis (SAR) is not just a commonly seen health problem in certain seasons. It is also a risk …Read the Rest

    Systems Biology and Biomarkers in Neuropsychiatry

    April 22, 2016
    Biomarkers

    Neuropsychiatric (NP) disorders such as autism spectrum disorders (ASD) are the leading causes of disability around the world. However, because …Read the Rest

    Biomarkers, Oncology, and Precision Medicine

    April 21, 2016
    Biomarkers

    The identification of biomarkers is becoming more and more important in biomedicine, especially for the clinical practice. This is because …Read the Rest

    Systems Biology Technologies and Cancer Immunotherapy

    April 19, 2016
    Systems Biology

    Decades of scientific studies have demonstrated the essential role of the immune system in cancer pathology and clinical treatment. The …Read the Rest

    Skin Disorders, Skinomics and Microarray Studies

    April 16, 2016
    Systems Biology

    The new field of “skinomics” refers to the use of systems biology and “omics” approaches in the studies of the …Read the Rest

    Systems Biomarkers and Skin Diseases

    April 12, 2016
    Systems Biology

    With the development of systems biology, bioinformatics, ‘omics’ studies, more and more discoveries are made in the disorders including cardiovascular …Read the Rest

    Alzheimer’s Disease and the Gene APOE (Apolipoprotein E)

    March 8, 2016
    Mind-Body

    The APOE gene has other symbols as “AD2”, “LPG”, “APO-E”, and “LDLCQ5”. It is located at 19q13.2. The APOE gene …Read the Rest

    Psychiatric Symptoms and the Gene SGCE (Sarcoglycan Epsilon)

    March 1, 2016
    Mind-Body

    The SGCE gene has other symbols as “ESG” and “DYT11”. It is located at 7q21.3. As a member of the …Read the Rest

    Epilepsy and the Gene KCNT1 (Potassium Sodium-Activated Channel Subfamily T member 1)

    February 25, 2016
    Brain

    The KCNT1 gene has other symbols as “ENFL5”, “SLACK”, “EIEE14”, “KCa4.1”, “Slo2.2”, and “bA100C15.2”. It is located at 9q34.3. Encoding …Read the Rest

    Neuropsychiatric Disorders and the Gene COMT (Catechol-O-Methyltransferase)

    February 23, 2016
    Mind-Body

    The COMT gene has another symbol as “HEL-S-98n”. It is located at 22q11.21. It is an important enzyme in the …Read the Rest

    Psychiatric Diseases and the Gene DISC1 (Disrupted in Schizophrenia 1)

    February 20, 2016
    Mind-Body

    The DISC1 gene has other symbols as “SCZD9” and “C1orf136”. It is located at 1q42.2. It is involved in the …Read the Rest

    Stress, Depression, Inflammation, and Personalized Medicine

    February 19, 2016
    Mind-Body

    Stress, Depression, Inflammation, and Personalized Medicine Psychological stress has been associated with higher levels of inflammation and the risks of …Read the Rest

    Systems Biology, Immunity, Biomarkers, and Aging

    January 8, 2016
    Systems Biology

    Many chronic diseases are age-associated, including Alzheimer’s disease, cardiovascular disease, type 2 diabetes, and cancer. The elevating incidence of these …Read the Rest

    Systems Biology, Lipidomics, and Cardiovascular Disease

    October 24, 2015
    Systems Biology

    Atherosclerosis involves a gradual process of inflammation with the stiffening of the arterial wall. This inflammatory condition can be caused …Read the Rest

    Network Interactions, Interactomes, and Drug Discovery

    October 18, 2015
    Systems Biology

    Because genes and proteins are functioning in complex networks and interactions, one molecule may influence other cellular elements in a …Read the Rest

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    Mind-Body, Personalized, and Systems Medicine